Polsachev V I, Alekseĭtseva S P, Lazarev V V, Braginskaia O V
Khirurgiia (Mosk). 1999(3):25-7.
On the basis of 1800 examinations of tumor cells the authors show possibility for accumulation of luminescent dye uranine by malignant cells. The conception of the mechanism of its accumulation, confirmed by the studies of reinoculated tumors of rats (60 examinations) is presented. Of 821 patients with ulcers of the stomach 641 had no luminescence; at repeated examination cancer and ulcer were revealed in 7 of them. Malignant transformation was verified by histologic method in 102 of 180 patients with luminescent ulcers. In 22 patients intestinal metaplasia was detected in the luminescence areas and in 40--there was a rough epitnelial dysplasia. At the examination of these patients two years later, cancer of the stomach at the sites of previously revealed luminescence was detected in 15 patients (26.3%).
基于对1800个肿瘤细胞的检查，作者表明恶性细胞有积累荧光染料尿酸的可能性。文中提出了其积累机制的概念，这一概念通过对大鼠再次接种肿瘤的研究（60次检查）得到了证实。在821例胃溃疡患者中，641例无荧光；再次检查时，其中7例发现有癌症和溃疡。180例有荧光溃疡的患者中，102例经组织学方法证实发生了恶性转化。在22例患者的荧光区域检测到肠化生，40例存在严重上皮发育异常。两年后对这些患者进行检查时，在先前发现有荧光的部位检测到15例胃癌（26.3%）。
