Krol A, Flynn C, Vlahov D, Miedema F, Coutinho R A, van Ameijden E J
Division of Public Health and Environment, Municipal Health Service, Amsterdam, The Netherlands.
Drug Alcohol Depend. 1999 Apr 1;54(2):145-54. doi: 10.1016/s0376-8716(98)00158-6.
Long-term effects of drug type and other drug use related risk factors on CD4+ cell decline were assessed in 224 HIV-infected injecting drug users (IDUs) from Baltimore (ALIVE), USA, and 63 IDUs from Amsterdam, The Netherlands. Higher frequencies of borrowing used injection equipment since 1980 resulted in a higher CD4+ count already present before seroconversion (P = 0.049). Use of mainly heroin in the seroconversion interval resulted in a sharper CD4+ decline until the first 6 months after seroconversion (P = 0.004), but CD4+ values converged later on. This finding might reconcile earlier discordant epidemiological and laboratory study results regarding the possible effects of heroin.
在美国巴尔的摩（ALIVE）的224名感染HIV的注射吸毒者（IDU）以及荷兰阿姆斯特丹的63名IDU中，评估了药物类型和其他与吸毒相关的风险因素对CD4 +细胞下降的长期影响。自1980年以来，借用使用过的注射设备的频率较高，导致在血清转化前就已经有较高的CD4 +细胞计数（P = 0.049）。在血清转化期间主要使用海洛因会导致在血清转化后的前6个月内CD4 +细胞下降更为明显（P = 0.004），但CD4 +值随后趋于一致。这一发现可能调和了早期关于海洛因可能影响的不一致的流行病学和实验室研究结果。
