芬兰注射吸毒者中CRF01-AE毒株引发的疫情中出现高血浆HIV载量。

High plasma HIV load in the CRF01-AE outbreak among injecting drug users in Finland.

作者信息

Kivelä Pia S, Krol Anneke, Salminen Mika O, Geskus Ronald B, Suni Jukka I, Anttila Veli-Jukka, Liitsola Kirsi, Zetterberg Veera, Miedema Frank, Berkhout Ben, Coutinho Roel A, Ristola Matti A

机构信息

Division of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland.

出版信息

Scand J Infect Dis. 2005;37(4):276-83.

PMID:15871166

Abstract

An explosive outbreak of HIV-1 caused by the recombinant subtype AE (CRF01-AE) was detected in 1998 among Finnish injecting drug users (IDUs). These IDUs were compared with IDUs from the Amsterdam Cohort Study (ACS) infected with subtype B, to detect possible differences between 2 western IDU cohorts infected with different subtypes. Markers for progression (viral load and CD4+lymphocyte count) were compared between 93 IDUs with CRF01-AE and 63 IDUs with subtype B. Only persons with a seroconversion interval =2 y were included. During 48 months of follow-up, both cohorts were similar in CD4+ cell decline, but the Finnish IDUs had 0.34-0.94 log10 copies/ml higher viral loads. The Amsterdam IDUs had a low viral load (<1000 copies/ml) significantly more often than the Finnish IDUs. The difference could not be explained by the use of antiretrovirals. The higher viral load may have contributed to the rapid spread of the recombinant virus in the Finnish outbreak.

摘要

1998年，在芬兰注射吸毒者（IDU）中检测到由重组AE亚型（CRF01 - AE）引起的HIV - 1爆发性疫情。将这些注射吸毒者与阿姆斯特丹队列研究（ACS）中感染B亚型的注射吸毒者进行比较，以检测两个感染不同亚型的西方注射吸毒者队列之间可能存在的差异。比较了93名感染CRF01 - AE的注射吸毒者和63名感染B亚型的注射吸毒者的疾病进展标志物（病毒载量和CD4 +淋巴细胞计数）。仅纳入血清转化间隔≥2年的个体。在48个月的随访期间，两个队列的CD4 +细胞下降情况相似，但芬兰注射吸毒者的病毒载量高0.34 - 0.94 log10拷贝/毫升。阿姆斯特丹注射吸毒者病毒载量低（<1000拷贝/毫升）的情况比芬兰注射吸毒者更常见。这种差异无法用抗逆转录病毒药物的使用来解释。较高的病毒载量可能促成了重组病毒在芬兰疫情中的快速传播。