Stinissen P, Raus J
Dr. I. Willems-Instituut, Limburgs Universitair Centrum, Diepenbeek, Belgium.
Acta Neurol Belg. 1999 Mar;99(1):65-9.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), leading to demyelination. Accumulating evidence suggests that MS is an autoimmune disease, mediated by autoreactive T cells with specificity for myelin antigens. The identity of the brain antigens, which are the primary targets of the autoimmune process remains unknown, but myelin basic protein (MBP) is a likely candidate. We will overview some of the experimental evidence, suggesting that MBP reactive T cells hold a central position in the pathogenesis of MS, and discuss how these autoreactive T cells can be therapeutically targeted by T cell vaccination.
多发性硬化症（MS）是一种中枢神经系统（CNS）的慢性炎症性疾病，可导致脱髓鞘。越来越多的证据表明，MS是一种自身免疫性疾病，由对髓鞘抗原具有特异性的自身反应性T细胞介导。作为自身免疫过程主要靶点的脑抗原的身份仍然未知，但髓鞘碱性蛋白（MBP）是一个可能的候选者。我们将概述一些实验证据，表明MBP反应性T细胞在MS发病机制中占据核心地位，并讨论如何通过T细胞疫苗对这些自身反应性T细胞进行治疗靶向。
