Schneider H, Fischer K, Fietkau R, Guthoff R F
Universitäts-Augenklinik Rostock.
Klin Monbl Augenheilkd. 1999 Feb;214(2):90-5. doi: 10.1055/s-2008-1034755.
The purpose of this report is to evaluate the efficacy of transpupillary thermotherapy (TTT) to treat choroidal melanoma.
17 patients with choroidal melanoma were treated, 6 patients with small tumors close to posterior pole received TTT only 11 patients were treated simultaneously with TTT and Ru 106 brachytherapy. To perform TTT a diode laser with a beam diameter of 1.5 to 3 millimeters was used. Exposure time ranged from 60 to 90 seconds until a light grey appearance of the retinal surface was reached. Follow-up examinations were performed at 1-month intervals. If the tumor was partially regressed additional TTT was performed to reach the endpoint of a chorioretinal scar.
All tumors exhibited a reduction of tumor height in a mean follow-up period of 14.25 months. Side effects were minimal.
Treatment with TTT may be useful as a complementary modality to brachytherapy. A longer follow-up time is necessary for final evaluation.
本报告旨在评估经瞳孔温热疗法（TTT）治疗脉络膜黑色素瘤的疗效。
17例脉络膜黑色素瘤患者接受治疗，6例靠近后极的小肿瘤患者仅接受TTT治疗，11例患者同时接受TTT和钌106近距离放射治疗。进行TTT时使用光束直径为1.5至3毫米的二极管激光。暴露时间为60至90秒，直至视网膜表面呈现浅灰色外观。每隔1个月进行一次随访检查。如果肿瘤部分消退，则进行额外的TTT治疗，直至达到脉络膜视网膜瘢痕的终点。
在平均14.25个月的随访期内，所有肿瘤的高度均有所降低。副作用极小。
TTT治疗可作为近距离放射治疗的补充方式。最终评估需要更长的随访时间。
