胃肠道恶性淋巴瘤

Malignant lymphoma of the gastrointestinal tract.

作者信息

Pandey M, Wadhwa M K, Patel H P, Kothari K C, Shah M, Patel D D

机构信息

Department of Surgical Oncology, NCH Compound, Asarwa, Ahmedabad, India.

出版信息

Eur J Surg Oncol. 1999 Apr;25(2):164-7. doi: 10.1053/ejso.1998.0620.

DOI:10.1053/ejso.1998.0620

PMID:10218459

Abstract

AIMS

The gastrointestinal tract (GIT) is the most common site of extra-nodal lymphoma. Most of these lymphomas arise from mucosa associated lymphoid tissue (MALT). We attempt in this study to define the natural history and treatment outcome of this type of lymphoma.

METHODS

We carried out a retrospective study of patients presenting at our centre with histopathological diagnosis of primary GIT lymphoma between 1990 and 1994.

RESULTS

Equal numbers of cases of stomach and small bowel lymphoma were found. Vomiting and feeling of fullness were the two most common presenting symptoms. Large cell type and high grade tumours were found to be the commonest histological types. All the patients were treated with surgery followed by chemotherapy. A 5-year disease-free survival (DFS) rate of 73%) was observed with a confidence interval of 0.65-1.35. Survival in stomach cancer was 73.5% (95% CI 0.26-1.74) while it was 76.4% in small bowel tumours (95% CI 0.54-1.46). The difference in survival was not statistically significant.

CONCLUSIONS

Although there is no consensus regarding treatment of primary GI lymphoma, surgery and adjuvant chemotherapy yield good survival.

摘要

目的

胃肠道（GIT）是结外淋巴瘤最常见的发病部位。这些淋巴瘤大多起源于黏膜相关淋巴组织（MALT）。本研究旨在明确此类淋巴瘤的自然病史和治疗结果。

方法

我们对1990年至1994年间在本中心就诊、经组织病理学诊断为原发性GIT淋巴瘤的患者进行了一项回顾性研究。

结果

发现胃癌和小肠淋巴瘤病例数相等。呕吐和饱腹感是最常见的两个症状。大细胞型和高级别肿瘤是最常见的组织学类型。所有患者均接受了手术治疗，随后进行化疗。观察到5年无病生存率（DFS）为73%，置信区间为0.65 - 1.35。胃癌患者的生存率为73.5%（95%CI 0.26 - 1.74），小肠肿瘤患者的生存率为76.4%（95%CI 0.54 - 1.46）。生存率的差异无统计学意义。