铁过载上调肺部血红素加氧酶1的速度比其他组织更快。

Iron overload upregulates haem oxygenase 1 in the lung more rapidly than in other tissues.

作者信息

Anning P B, Chen Y, Lamb N J, Mumby S, Quinlan G J, Evans T W, Gutteridge J M

机构信息

Unit of Critical Care, Royal Brompton and Harefield NHS Trust, Imperial College of Science, Technology and Medicine, London, UK.

出版信息

FEBS Lett. 1999 Mar 19;447(1):111-4. doi: 10.1016/s0014-5793(99)00250-1.

DOI:10.1016/s0014-5793(99)00250-1

PMID:10218593

Abstract

Haem oxygenase-1 is upregulated by numerous insults, including oxidative stress, and under such circumstances it is considered to be a protective stratagem. We have measured the haem oxygenase-1 expression in heart, lung and liver tissues of control and iron-overloaded rats. Lung tissue from iron-overloaded rats displayed a significant increase in the haem oxygenase-1 protein but no changes in haem oxygenase-1 mRNA. Conversely, heart tissue showed a significant increase in haem oxygenase-1 mRNA but no changes in haem oxygenase-1 protein. We conclude that during oxidative stress caused by iron overload, lung tissue responds with a rapid upregulation of haem oxygenase-1 levels.

摘要

血红素加氧酶-1可被多种损伤因素上调，包括氧化应激，在这种情况下它被认为是一种保护策略。我们已经检测了对照大鼠和铁过载大鼠心脏、肺和肝脏组织中血红素加氧酶-1的表达。铁过载大鼠的肺组织中血红素加氧酶-1蛋白显著增加，但血红素加氧酶-1 mRNA没有变化。相反，心脏组织中血红素加氧酶-1 mRNA显著增加，但血红素加氧酶-1蛋白没有变化。我们得出结论，在铁过载引起的氧化应激过程中，肺组织通过快速上调血红素加氧酶-1水平做出反应。