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[谷氨酸对急慢性缺氧大鼠肝脏、心脏和肾脏线粒体中微量元素含量的影响]

[Effect of glutamate on the trace element content in the mitochondria of the liver, heart and kidneys of rats with acute and chronic hypoxia].

作者信息

Glotov N A, Vul'fson A M

出版信息

Ukr Biokhim Zh. 1976 Sep-Oct;48(5):559-62.

PMID:1021908
Abstract

Acute hypoxia ("height" 8000 metres, 60 minutes) decreases concentration of copper, zinc and magnesium in mitochondria of the liver, kidney, that of copper and magnesium decreases in the heart. Chronic hypoxia ("height" 6000 metres, 6 hours a day for 2 weeks) also causes a decrease in the concentration of copper, zinc and magnesium in mitochondria of the liver, kidney and that of copper and magnesium--in the heart. Glutamic acid (acute and chronic hypoxia) increases the level of copper, zinc and magnesium in mitochondria of the liver, heart and kidney of albino rats which is close to its values in the normal animals.

摘要

急性缺氧(“海拔”8000米,60分钟)会降低肝脏、肾脏线粒体中铜、锌和镁的浓度,心脏中铜和镁的浓度也会降低。慢性缺氧(“海拔”6000米,每天6小时,持续2周)同样会导致肝脏、肾脏线粒体中铜、锌和镁的浓度降低,心脏中铜和镁的浓度也降低。谷氨酸(急性和慢性缺氧情况下)可提高白化大鼠肝脏、心脏和肾脏线粒体中铜、锌和镁的水平,使其接近正常动物的水平。

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