Johnson M P, Freedman A L
Department of Pediatric General and Thoracic Surgery, Children's Hospital of Philadelphia, PA 19104, USA.
Curr Opin Obstet Gynecol. 1999 Apr;11(2):185-94. doi: 10.1097/00001703-199904000-00011.
Our understanding of the causes, mechanisms, and prenatal management of fetal obstructive uropathy has increased significantly. Improved methods of prenatal evaluation have allowed the better selection of fetuses for invasive therapy, and studies indicate better survival and renal outcomes in carefully selected cases. New biological markers in fetal urine may provide a better understanding of the pathological processes of renal damage, additional prognostic markers, and lead to non-surgical approaches to preventing renal damage.
我们对胎儿梗阻性肾病的病因、机制及产前管理的理解有了显著提高。改进的产前评估方法使我们能够更好地选择适合进行侵入性治疗的胎儿，而且研究表明，在经过精心挑选的病例中，胎儿的存活率和肾脏预后更佳。胎儿尿液中的新生物标志物可能有助于更好地理解肾损伤的病理过程，提供更多的预后标志物，并催生预防肾损伤的非手术方法。
