中子-γ辐射对大鼠脑内多巴胺和5-羟色胺代谢的影响：区域分析

Effect of neutron-gamma radiation on dopamine and serotonin metabolism in the rat brain: a regional analysis.

作者信息

Foulon O, Lalouette F, Lambert F, Martin S, Fatôme M, Martin C

机构信息

Department of Radiobiology, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France.

出版信息

J Neurosci Res. 1999 Mar 15;55(6):770-5. doi: 10.1002/(SICI)1097-4547(19990315)55:6<770::AID-JNR11>3.0.CO;2-A.

DOI:10.1002/(SICI)1097-4547(19990315)55:6<770::AID-JNR11>3.0.CO;2-A

PMID:10220117

Abstract

The concentrations of dopamine (DA) and its metabolites and the levels of 5-hydroxyindoleacetic acid (5-HIAA), the metabolite of serotonin, were determined in discrete cerebral areas of rats 3 hr after (neutron-gamma) irradiation at 4 and 7 Gy. After the 7 Gy irradiation, no significant effect was observed. After the 4 Gy exposure, the most marked difference between irradiated and control rats was in the levels of DA and its metabolites in the striatum. We observed a decrease of DA, HVA, and DOPAC levels in the striatum and an opposite pattern in the substantia nigra. Whatever the brain area observed, an increase of 5-HIAA levels was noted.

摘要

在4 Gy和7 Gy的（中子-γ）辐射后3小时，测定大鼠不同脑区中多巴胺（DA）及其代谢产物的浓度以及血清素代谢产物5-羟吲哚乙酸（5-HIAA）的水平。7 Gy辐射后未观察到显著影响。4 Gy照射后，照射组和对照组大鼠之间最明显的差异在于纹状体中DA及其代谢产物的水平。我们观察到纹状体中DA、高香草酸（HVA）和3,4-二羟基苯乙酸（DOPAC）水平降低，而黑质中则呈现相反的模式。无论观察哪个脑区，均发现5-HIAA水平升高。