Tashiro K, Ikegawa M, Yabe D, Honjo T
Center for Molecular Biology and Genetics, Kyoto University.
Nihon Rinsho. 1999 Apr;57(4):967-74.
Three genes which have variants acting as anti-HIV-1 were described so far. Among three, two are genes encoding receptors for chemokines, namely CCR5 and CCR2, which act as entry coreceptors for HIV-1 virus. The other gene is SDF1 gene. SDF-1, a cytokine belonging to the chemokine family has an inhibitory activity against the HIV-1 infection, because SDF-1 Is the physiological ligand for CXCR4, the entry coreceptor for T tropic HIV-1 virus. Recently, an SDF1 gene polymorphism was figured out to be one of the human genetic factors which regulate the period between the HIV-1 infection and the AIDS onset. By this finding, it was strongly suggested that SDF-1 regulates the onset of AIDS in the actual human population.
迄今为止，已发现三种具有抗HIV-1作用变体的基因。其中，两种是编码趋化因子受体的基因，即CCR5和CCR2，它们作为HIV-1病毒的进入共受体。另一个基因是SDF1基因。SDF-1是一种属于趋化因子家族的细胞因子，对HIV-1感染具有抑制活性，因为SDF-1是T嗜性HIV-1病毒进入共受体CXCR4的生理配体。最近，SDF1基因多态性被认为是调节HIV-1感染与艾滋病发病之间时间间隔的人类遗传因素之一。通过这一发现，强烈提示SDF-1在实际人群中调节艾滋病的发病。
