Lentz R D, Brown D M, Kjellstrand C M
Ann Intern Med. 1978 Dec;89(6):941-4. doi: 10.7326/0003-4819-89-6-941.
Aspects of phosphate biochemistry pertinent to therapy, the distribution of phosphorus in body compartments, therapeutic phosphorus preparations, prevention of hypophosphatemia, therapeutic guidelines, and side-effects of phosphorus therapy are reviewed. Severe hypophosphatemia (less than 0.32 mmol/litre or less than 1 mg/dl) can occur with normal or depleted body stores. Because a large amount of phosphorus may shift rapidly between the extracellular and intracellular or bone compartments, the size of a possible total body deficit cannot be estimated from the serum phosphorus level. Similar shifts may occur unpredictably during repair of hypophosphatemia. Therefore, correction of hypophosphatemia in any patient must be empiric and the response of serum levels to therapy should be followed closely. We discuss a method likely to correct hypophosphatemia while minimizing side-effects.
本文综述了与治疗相关的磷酸盐生物化学方面、磷在体内各腔室的分布、治疗用磷制剂、低磷血症的预防、治疗指南以及磷治疗的副作用。严重低磷血症（低于0.32 mmol/升或低于1 mg/dl）可在体内储备正常或减少的情况下发生。由于大量磷可在细胞外与细胞内或骨腔室之间迅速转移，因此无法根据血清磷水平估计可能的全身缺乏量。在低磷血症纠正过程中，类似的转移可能不可预测地发生。因此，任何患者低磷血症的纠正都必须凭经验进行，并且应密切跟踪血清水平对治疗的反应。我们讨论了一种可能在纠正低磷血症的同时将副作用降至最低的方法。
