β-微管蛋白的301至314个氨基酸残基不是慢性炎症性脱髓鞘性多发性神经病血清IgM抗体的靶表位。

The 301 to 314 amino acid residue of beta-tubulin is not a target epitope for serum IgM antibodies in chronic inflammatory demyelinating polyneuropathy.

作者信息

Tagawa Y, Yuki N, Hirata K

机构信息

Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.

出版信息

J Neurol Sci. 1999 Feb 1;163(1):44-6. doi: 10.1016/s0022-510x(99)00003-9.

DOI:10.1016/s0022-510x(99)00003-9

PMID:10223409

Abstract

Connolly et al. [Neurology 48 (1997) 243] reported that IgM M-proteins from three patients selectively binds to an epitope on beta-tubulin that consists of amino acids 301 to 314. We therefore investigated whether these 14 amino acid residues beta301-314 are the target epitope for serum IgMs in sera from 67 patients with chronic inflammatory demyelinating polyneuropathy (CIDP), 50 with Guillain-Barré syndrome, 50 with motor neuron diseases, and 50 normal controls. IgM anti-beta301-314 antibodies were not restricted to nor were selectively associated with CIDP. We conclude that beta301-314 is not a target epitope for serum IgMs in CIDP.

摘要

康诺利等人[《神经病学》48(1997)243]报告称，来自三名患者的IgM M蛋白选择性结合β-微管蛋白上由氨基酸301至314组成的一个表位。因此，我们研究了这14个氨基酸残基β301 - 314是否是67例慢性炎性脱髓鞘性多发性神经病（CIDP）患者、50例吉兰 - 巴雷综合征患者、50例运动神经元疾病患者以及50名正常对照者血清中血清IgM的靶表位。IgM抗β301 - 314抗体并不局限于CIDP，也未与CIDP选择性相关。我们得出结论，β301 - 314不是CIDP患者血清IgM的靶表位。