肢体恶性纤维组织细胞瘤
Malignant fibrous histiocytoma of the extremity.
作者信息
Salo J C, Lewis J J, Woodruff J M, Leung D H, Brennan M F
机构信息
Department of Surgery, Loma Linda University, California, USA.
出版信息
Cancer. 1999 Apr 15;85(8):1765-72.
BACKGROUND
This study examines prognostic factors and outcomes for a group of patients with malignant fibrous histiocytoma of the extremity treated at a single referral institution.
METHODS
A total of 239 patients underwent complete surgical excision between July 1982 and July 1996 and were followed prospectively.
RESULTS
The overall 5-year and 10-year disease specific survival rates for this group were 65% and 59%, respectively. Age >50 years, tumor location, and presentation with local recurrence were all associated with increased risk of local recurrence. Tumor size, grade, depth, and presentation with local recurrence were all associated with adverse disease specific and metastasis free survival. Tumor size > or = 10 cm was associated with a particularly unfavorable outcome.
CONCLUSIONS
The majority of malignant fibrous histiocytomas of the extremity are associated with a relatively favorable prognosis. Size > or = 5 cm, deep depth, and high grade are all unfavorable factors. Size > or = 10 cm is associated with an even more unfavorable prognosis.
背景
本研究调查了在一家转诊机构接受治疗的一组肢体恶性纤维组织细胞瘤患者的预后因素及结果。
方法
1982年7月至1996年7月期间，共有239例患者接受了完整的手术切除，并进行了前瞻性随访。
结果
该组患者的5年和10年疾病特异性生存率分别为65%和59%。年龄>50岁、肿瘤位置以及出现局部复发均与局部复发风险增加相关。肿瘤大小、分级、深度以及出现局部复发均与不良的疾病特异性生存率和无转移生存率相关。肿瘤大小≥10 cm与特别不良的预后相关。
结论
大多数肢体恶性纤维组织细胞瘤的预后相对良好。大小≥5 cm、深度较深和高级别均为不利因素。大小≥10 cm与更差的预后相关。
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