Shinohara N, Yokoyama K, Masuda S, Kitajima T
Gan To Kagaku Ryoho. 1987 May;14(5 Pt 2):1614-9.
Thirty-six patients with soft tissue malignant fibrous histiocytoma were followed up. At the time of this study, 14 of the 36 patients were alive and the average follow-up period was 59.3 months. The average age at initial diagnosis was 62.1 years. Of the 36 patients, 13 were initially treated by us. All of the marginal excision cases (17) showed recurrence. Five of 8 additional excision cases had residual tumor and three of these showed recurrence. Those cases given primary wide excision (5) showed no local recurrence. One out of 3 amputation cases showed recurrence five years after the operation. Thus, the total recurrence rate was 64%. The average period of recurrence was 9.3 months (n = 21). Radiotherapy was effective in four patients among 11 irradiated cases. Chemotherapy is difficult to apply, since patients are generally too old to tolerate intensive chemotherapy and also the drug-sensitivity is low. For this reason, we have insufficient clinical experience to make an evaluation. Five-year survival rate was 45% and 10-year survival, 30%. Early detection of the tumor and adequate initial surgery are the best ways of improving the results of treatment for MFH. Chemotherapy and radiotherapy might achieve adjuvant effects and produce better results.
对36例软组织恶性纤维组织细胞瘤患者进行了随访。在本研究时，36例患者中有14例存活，平均随访期为59.3个月。初次诊断时的平均年龄为62.1岁。36例患者中，13例最初由我们治疗。所有边缘切除病例（17例）均出现复发。另外8例扩大切除病例中有5例有残留肿瘤，其中3例出现复发。那些接受初次广泛切除的病例（5例）未出现局部复发。3例截肢病例中有1例在术后5年出现复发。因此，总复发率为64%。复发的平均时间为9.3个月（n = 21）。11例接受放疗的病例中有4例放疗有效。由于患者普遍年龄较大，难以耐受强化化疗，且药物敏感性较低，因此化疗难以应用。由于这个原因，我们没有足够的临床经验进行评估。5年生存率为45%，10年生存率为30%。肿瘤的早期发现和充分的初次手术是改善恶性纤维组织细胞瘤治疗效果的最佳方法。化疗和放疗可能会起到辅助作用并产生更好的效果。
