β-内酰胺类抗生素对来自大肠杆菌K-12和巨大芽孢杆菌KM的颗粒组分在体外进行肽聚糖交联的影响。
Effect of beta-lactam antibiotics on in vitro peptidoglycan cross-linking by a particulate fraction from Escherichia coli K-12 and Bacillus megaterium KM.
作者信息
Oka T, Fujita H
出版信息
Antimicrob Agents Chemother. 1978 Oct;14(4):625-7. doi: 10.1128/AAC.14.4.625.
Abstract
The binding constants of several beta-lactam antibiotics towards penicillin-binding components in Escherichia coli K-12 (Spratt, Eur. J. Biochem. 72:341-352, 1977) and the antibiotic concentrations required to inhibit the peptidoglycan transpeptidase of E. coli 50% were compared. Penicillin-binding component 1B may have been the transpeptidase working in vitro. The structure-activity relationships of beta-lactam antibiotics and the mechanisms of action in E. coli and Bacillus megaterium are discussed.
摘要
比较了几种β-内酰胺抗生素与大肠杆菌K-12中青霉素结合成分的结合常数（斯普拉特，《欧洲生物化学杂志》72:341 - 352，1977）以及抑制大肠杆菌肽聚糖转肽酶50%所需的抗生素浓度。青霉素结合成分1B可能是体外起作用的转肽酶。讨论了β-内酰胺抗生素的构效关系以及在大肠杆菌和巨大芽孢杆菌中的作用机制。
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本文引用的文献
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Enzymatic synthesis of cell wall mucopeptide in a particulate preparation of Escherichia coli.大肠杆菌颗粒制剂中细胞壁粘肽的酶促合成。
Biochem Biophys Res Commun. 1966 May 25;23(4):466-72. doi: 10.1016/0006-291x(66)90751-0.
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Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.青霉素与细菌细胞的相互作用：青霉素结合蛋白和青霉素敏感酶。
Bacteriol Rev. 1974 Sep;38(3):291-335. doi: 10.1128/br.38.3.291-335.1974.
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FL-1060: a new penicillin with a unique mode of action.FL-1060：一种具有独特作用方式的新型青霉素。
Biochem Biophys Res Commun. 1973 Apr 16;51(4):863-8. doi: 10.1016/0006-291x(73)90006-5.
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Studies on the elongation of bacterial cell wall peptidoglycan and its inhibition by penicillin.细菌细胞壁肽聚糖的伸长及其受青霉素抑制的研究。
Ann N Y Acad Sci. 1974 May 10;235(0):326-47. doi: 10.1111/j.1749-6632.1974.tb43275.x.
6
Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12.参与大肠杆菌K12分裂、伸长和形态形成的不同青霉素结合蛋白。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):2999-3003. doi: 10.1073/pnas.72.8.2999.
7
Mode of action of penicillins in vivo and in vitro in Bacillus megaterium.青霉素在巨大芽孢杆菌体内和体外的作用模式。
Antimicrob Agents Chemother. 1976 Oct;10(4):579-91. doi: 10.1128/AAC.10.4.579.
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Identification of the major penicillin-binding proteins of Escherichia coli as D-alanine carboxypeptidase IA.鉴定大肠杆菌的主要青霉素结合蛋白为D-丙氨酸羧肽酶IA。
J Bacteriol. 1976 Jul;127(1):660-3. doi: 10.1128/jb.127.1.660-663.1976.
9
Thermosensitive mutation in Escherichia coli simultaneously causing defects in penicillin-binding protein-1Bs and in enzyme activity for peptidoglycan synthesis in vitro.大肠杆菌中的热敏突变同时导致青霉素结合蛋白-1B的缺陷以及体外肽聚糖合成酶活性的缺陷。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5472-6. doi: 10.1073/pnas.74.12.5472.
10
Simultaneous deletion of D-alanine carboxypeptidase IB-C and penicillin-binding component IV in a mutant of Escherichia coli K12.在大肠杆菌K12突变体中同时缺失D-丙氨酸羧肽酶IB-C和青霉素结合成分IV。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):2980-4. doi: 10.1073/pnas.74.7.2980.
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