苯并[a]芘透过人颊黏膜和阴道黏膜的情况。

Penetration of benzo[a]pyrene through human buccal and vaginal mucosa.

作者信息

van der Bijl P, van Eyk A D

机构信息

Oral and Dental Research Institute, Faculty of Dentistry, University of Stellenbosch, Tygerberg, South Africa.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Apr;87(4):452-5. doi: 10.1016/s1079-2104(99)70245-3.

DOI:10.1016/s1079-2104(99)70245-3

PMID:10225628

Abstract

OBJECTIVE

The aim of this study was to compare buccal and vaginal mucosa with respect to their permeability to a potent carcinogen, benzo[a]pyrene.

STUDY DESIGN

Six clinically healthy vaginal mucosa specimens (mean patient age +/- standard deviation, 52+/-13.4 years; age range, 37-69 years) and 6 buccal mucosa specimens (from 5 male patients and 1 female patient: mean patient age +/- standard deviation, 32+/-5.2 years; age range, 24-39 years) were obtained during surgery. In vitro flux rates of benzo[a]pyrene across specimens were determined through use of a flow-through diffusion apparatus. Analysis of variance, a Duncan multiple range test, and an unpaired t test were used to determine steady state kinetics and flux differences over time intervals.

RESULTS

No statistically significant differences were observed between the overall mean flux values of benzo[a]pyrene across the 2 kinds of mucosa.

CONCLUSIONS

The findings further support the hypothesis that human vaginal mucosa can be used as a model for buccal mucosa in studies of permeability to various chemical compounds.

摘要

目的

本研究旨在比较颊黏膜和阴道黏膜对强效致癌物苯并[a]芘的通透性。

研究设计

在手术过程中获取了6份临床健康的阴道黏膜标本（患者平均年龄±标准差，52±13.4岁；年龄范围，37 - 69岁）和6份颊黏膜标本（来自5名男性患者和1名女性患者：患者平均年龄±标准差，32±5.2岁；年龄范围，24 - 39岁）。通过使用流通扩散装置测定苯并[a]芘在标本上的体外通量率。采用方差分析、邓肯多重范围检验和非配对t检验来确定稳态动力学以及不同时间间隔内的通量差异。