Murashita T, Hatta E, Miyatake T, Kubota T, Sasaki S, Shiiya N, Matsui Y, Sakuma M, Yasuda K
Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
Kyobu Geka. 1999 Apr;52(4):295-300.
Although the postoperative outcome in patients with incomplete atrioventricular septal defect (iAVSD) is excellent, deterioration of mitral valve regurgitation (MR) is still remained to be resolved. Therefore, this study was undertaken to compare surgical procedures for mitral cleft repair with their long-term results of MR. From 1991 to 1996, 52 patients underwent surgical repair of iAVSD. Age at operation ranged from 2 months to 62 years old with mean age of 14.2 years. Mean follow-up period was 8.6 +/- 4.4 years. All patients underwent patch closure of ostium primum defect. Two patients did not have cleft (Group A). Seven patients did not close the cleft at all (Group B), while 40 patients had the repair of valve by closing cleft near septal attachment only (Group C). The latest 3 patients had the complete closure of cleft from annulus to margin of leaflet where chorda is attached. MR was evaluated by echocardiography grading 0 to IV and regurgitation more than grade II was considered to be significant. In Group A, MR remained grade I. In Group B, MR was deteriorated in 5 patients (71%). Consequently, 6 patients (86%) had grade II or more regurgitation and 4 patients (57%) revealed grade III/IV regurgitation including one (14%) reoperation. In Group C, MR was deteriorated in 10 patients (55%). Consequently, 22 patients (86%) had grade II or more regurgitation and 5 patients (13%) had grade III/IV regurgitation including 3 (7.5%) reoperations. In Group D, no deterioration of MR was noted and all had grade I or less regurgitation. These results suggest that the closure of cleft near septal attachment is not sufficient to prevent MR in late phase and the complete closure of cleft from annulus to margin of leaflet, where chorda is attached, would be useful to prevent the deterioration of MR in late phase.
尽管不完全性房室间隔缺损(iAVSD)患者的术后结局良好,但二尖瓣反流(MR)的恶化问题仍有待解决。因此,本研究旨在比较二尖瓣裂修复的手术方法及其MR的长期结果。1991年至1996年,52例患者接受了iAVSD的手术修复。手术年龄从2个月至62岁不等,平均年龄为14.2岁。平均随访期为8.6±4.4年。所有患者均接受了原发孔缺损的补片闭合术。2例患者没有裂(A组)。7例患者完全未闭合裂(B组),而40例患者仅通过在间隔附着处附近闭合裂来修复瓣膜(C组)。最近的3例患者从瓣环到腱索附着的瓣叶边缘完全闭合了裂。通过超声心动图将MR分为0至IV级进行评估,反流超过II级被认为是严重的。在A组中,MR仍为I级。在B组中,5例患者(71%)的MR恶化。因此,6例患者(86%)有II级或以上反流,4例患者(57%)表现为III/IV级反流,其中1例(14%)再次手术。在C组中,10例患者(55%)的MR恶化。因此,22例患者(86%)有II级或以上反流,5例患者(13%)有III/IV级反流,其中3例(7.5%)再次手术。在D组中,未发现MR恶化,所有患者的反流均为I级或以下。这些结果表明,在间隔附着处附近闭合裂不足以预防晚期MR,从瓣环到腱索附着的瓣叶边缘完全闭合裂可能有助于预防晚期MR的恶化。