D'Agostino P A, Hancock J R, Provost L R
Defence Research Establishment Suffield, Alberta, Canada.
J Chromatogr A. 1999 Apr 2;837(1-2):93-105. doi: 10.1016/s0021-9673(99)00102-8.
Packed capillary column liquid chromatography (LC)-electrospray mass spectrometry (ESI-MS) was used for the first time to detect and identify O-ethyl, S-[2-(diisopropylamino)ethyl] methylphosphonothiolate (VX) and its degradation products, including compounds containing a P-CH3 bond, bis(diisopropylamino)thioalkanes and ureas commonly employed as VX stabilizers. The reported ESI-MS data were generally acquired with a higher sampling cone voltage, a setting that promoted collisionally activated dissociation, and resulted in the acquisition in informative mass spectra containing both molecular and product ion information. The developed method appears to be an attractive alternative to GC-MS for the analysis of aqueous sample containing the degradation products of VX, since they may be analysed directly with little risk of thermal decomposition and without the need for additional sample handling or derivatization. Application of this method to a degraded VX sample resulted in the detection of a number of novel polar and higher-molecular-mass degradation products, not previously associated with VX during GC-MS analysis.
填充毛细管柱液相色谱（LC）-电喷雾质谱（ESI-MS）首次用于检测和鉴定O-乙基-S-[2-（二异丙基氨基）乙基]甲基硫代膦酸酯（VX）及其降解产物，包括含P-CH3键的化合物、双（二异丙基氨基）硫代烷烃以及常用作VX稳定剂的脲。报道的ESI-MS数据通常在较高的采样锥电压下采集，该设置会促进碰撞激活解离，并导致采集到包含分子离子和产物离子信息的信息丰富的质谱图。对于分析含有VX降解产物的水性样品，所开发的方法似乎是气相色谱-质谱联用（GC-MS）的一种有吸引力的替代方法，因为这些样品可以直接分析，几乎没有热分解风险，也无需额外的样品处理或衍生化。将该方法应用于降解的VX样品，结果检测到了许多新型的极性和高分子量降解产物，这些产物在GC-MS分析中以前未与VX相关联。
