Shiga S, Koyanagi I, Ohsaga J, Ichiyama S, Kannagi R
Hematology Division of Central Clinical Laboratory, Kyoto University Hospital.
Rinsho Byori. 1999 Mar;47(3):281-8.
Age and sex dependent differences in the clinical reference values for white blood cell(WBC) count, WBC differential including segmented neutrophils(SEG), band neutrophils(BAND), lymphocytes (LYMPH), monocytes(MONO), eosinophils(EOSINO), basophils(BASO), platelet count(PLT) and mean platelet volume(MPV) were calculated by the iterative truncation method with correction(Usui's method) using the result from tests on 6,300 patient specimens obtained at Kyoto University Hospital. WBC counts exhibited log-normal distribution in all age either in male and female. PLT counts and MPV showed normal or log-normal distribution. WBC differential (SEG, BAND, LYMPH, MONO, EOSINO, BASO) usually showed log-normal distribution. As to the reference value for WBC, high limit values gradually decreased in the age range of 5-14 year old in males and females. After 15 year old, it gradually increased and reached adult's level. Low limit values for WBC gradually decreased with age both in males and females. The reference value for SEG showed similar change to WBC. The reference value for LYMPH gradually decreased age both in males and females. The reference values for BAND, MONO, EOSINO, BASO were generated by the percentile method instead of the iterative truncation method because of the strong deviation in the distribution pattern. BAND, MONO and BASO values were very stable for all ages in males and females. High limit values for EOSINO in the age range of 5-10 year old in males and females remained constant, and gradually decreased in 10-20 year old, and were stable at ages above 20 year old. PLT counts gradually decreased with age, and the MPV remained constant in all age populations both in male and female.
利用京都大学医院6300份患者样本的检测结果，采用带校正的迭代截断法（臼井法）计算了白细胞（WBC）计数、白细胞分类（包括分叶中性粒细胞（SEG）、杆状核中性粒细胞（BAND）、淋巴细胞（LYMPH）、单核细胞（MONO）、嗜酸性粒细胞（EOSINO）、嗜碱性粒细胞（BASO））、血小板计数（PLT）和平均血小板体积（MPV）的临床参考值的年龄和性别依赖性差异。WBC计数在所有年龄段的男性和女性中均呈对数正态分布。PLT计数和MPV呈正态或对数正态分布。白细胞分类（SEG、BAND、LYMPH、MONO、EOSINO、BASO）通常呈对数正态分布。关于WBC的参考值，男性和女性在5至14岁年龄范围内的高限值逐渐降低。15岁以后，它逐渐升高并达到成人水平。男性和女性的WBC低限值均随年龄逐渐降低。SEG的参考值变化与WBC相似。LYMPH的参考值在男性和女性中均随年龄逐渐降低。由于分布模式存在强烈偏差，BAND、MONO、EOSINO、BASO的参考值采用百分位数法而非迭代截断法生成。BAND、MONO和BASO的值在男性和女性的所有年龄段都非常稳定。男性和女性在5至10岁年龄范围内的EOSINO高限值保持不变，在10至20岁逐渐降低，在20岁以上稳定。PLT计数随年龄逐渐降低，MPV在所有年龄组的男性和女性中均保持不变。
