Malanin K, Kolari P J, Havu V K
Department of Dermatology, University of Turku, Finland.
Acta Derm Venereol. 1999 Mar;79(2):156-60. doi: 10.1080/000155599750011435.
In an attempt to clarify the pathophysiology of haemodynamics in legs with venous ulcer we investigated the effect of a single intermittent pneumatic compression treatment on the peripheral resistance of leg arteries and the cutaneous laser Doppler flux in the leg. Eight patients with venous leg ulcers and 10 subjects with healthy legs were investigated. Doppler waveforms of the leg arteries and laser Doppler flux of the leg skin were recorded before and after a single intermittent pneumatic compression treatment with the subjects in a recumbent position. In the legs with venous ulcer, the peripheral resistance of the arteries was lower and the laser Doppler flux was greater, compared with healthy legs (p = 0.003 and p = 0.002, respectively). A single intermittent pneumatic compression treatment raised the peripheral resistance in the arteries of legs with ulcer and laser Doppler flux of the skin more in ulcer legs than in healthy legs (p = 0.046 and p = 0.034, respectively). These findings suggest that removal of oedema causes redistribution of skin blood flow in the legs with venous ulcer favouring the superficial capillary perfusion. This could explain why compression treatment promotes the healing of venous leg ulcers.
为了阐明患有静脉溃疡的腿部血流动力学的病理生理学，我们研究了单次间歇性气动压迫治疗对腿部动脉外周阻力和腿部皮肤激光多普勒血流的影响。对8例患有腿部静脉溃疡的患者和10例腿部健康的受试者进行了研究。在受试者卧位时，记录单次间歇性气动压迫治疗前后腿部动脉的多普勒波形和腿部皮肤的激光多普勒血流。与健康腿部相比，患有静脉溃疡的腿部动脉外周阻力较低，激光多普勒血流较高（分别为p = 0.003和p = 0.002）。单次间歇性气动压迫治疗使患有溃疡的腿部动脉外周阻力和皮肤激光多普勒血流的增加幅度在溃疡腿部比在健康腿部更大（分别为p = 0.046和p = 0.034）。这些发现表明，消除水肿会导致患有静脉溃疡的腿部皮肤血流重新分布，有利于浅表毛细血管灌注。这可以解释为什么压迫治疗能促进腿部静脉溃疡的愈合。
