Jacoby R K
J Rheumatol. 1976 Dec;3(4):384-9.
Living adult human articular cartilage has been maintained in tissue culture for eight days. Cartilage explants were cultured in one of three concentrations of hydrocortisone acetate or as control explants without this drug. The concentrations of hydrocortisone used were 0.01 microng/ml, 0.1 microng/ml and 1.0 mg/ml. The amount of proteoglycan shed into the medium was measured and no significant difference was found between the explants exposed to hydrocortisone and those that were not. These results suggest that hydrocortisone does not have a catabolic effect on the proteoglycan of articular cartilage. The widely held view that intra-articular corticosteroid injection causes cartilage damage, must remain in doubt.
成年人类活体关节软骨已在组织培养中维持了八天。软骨外植体在三种浓度的醋酸氢化可的松之一中培养，或作为不含该药物的对照外植体培养。所使用的氢化可的松浓度分别为0.01微克/毫升、0.1微克/毫升和1.0毫克/毫升。测量了释放到培养基中的蛋白聚糖量，发现暴露于氢化可的松的外植体与未暴露的外植体之间没有显著差异。这些结果表明，氢化可的松对关节软骨的蛋白聚糖没有分解代谢作用。关于关节内注射皮质类固醇会导致软骨损伤这一广泛持有的观点，仍值得怀疑。
