足底纤维瘤病：一项免疫组织化学和超微结构研究。
Plantar fibromatosis: an immunohistochemical and ultrastructural study.
作者信息
de Palma L, Santucci A, Gigante A, Di Giulio A, Carloni S
机构信息
Department of Orthopaedics, University of Ancona, Italy.
出版信息
Foot Ankle Int. 1999 Apr;20(4):253-7. doi: 10.1177/107110079902000408.
The analogies between plantar fibromatosis and Dupuytren's disease (palmar fibromatosis) are well known. The latter is clinically more frequent and has been the object of extensive immunohistochemical and ultrastructural studies, with a view to investigating its pathogenesis. By contrast, such data on plantar fibromatosis are quite scarce. A histochemical, immunohistochemical, and ultrastructural study was performed on nodule tissue from six patients who were subjected to total fasciectomy for plantar fibromatosis. The study of myofibroblasts revealed features suggestive of their fibroblastic origin and evidenced a cytoskeleton and an extracellular filamentous system that could enable myofibroblasts to generate and exert the intracellular forces that contribute to the contraction of the aponeurosis. These aspects are similar to those observed in Dupuytren's disease and seem to lend support to the theory that the two diseases are expressions of the same disorder.
足底纤维瘤病与掌腱膜挛缩症（掌部纤维瘤病）之间的相似之处广为人知。后者在临床上更为常见，并且一直是广泛的免疫组织化学和超微结构研究的对象，旨在探究其发病机制。相比之下，关于足底纤维瘤病的此类数据相当匮乏。对6例因足底纤维瘤病接受全筋膜切除术患者的结节组织进行了组织化学、免疫组织化学和超微结构研究。对肌成纤维细胞的研究揭示了提示其成纤维细胞起源的特征，并证明了一种细胞骨架和细胞外丝状系统，该系统可使肌成纤维细胞产生并施加有助于腱膜收缩的细胞内力。这些方面与在掌腱膜挛缩症中观察到的相似，似乎支持了这两种疾病是同一病症表现的理论。
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