McLaren J W, Bachman L A, Brubaker R F
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
J Ocul Pharmacol Ther. 1999 Apr;15(2):107-16. doi: 10.1089/jop.1999.15.107.
The purpose of this study was to measure the effect of topical ibopamine and epinephrine on intraocular pressure in undisturbed rabbits. Six pigmented rabbits were outfitted with a telemetric transducer system connected via catheter to the vitreous cavity of one eye for continuous monitoring of intraocular pressure. After entrainment to a 12 hour light, 12 hour dark cycle and after stabilization of the circadian rhythm of intraocular pressure, the animals were tested with 2% ibopamine and 2% epinephrine. Each drug was instilled during the light phase and during the dark phase of the circadian cycle. When administered during the light phase, both drugs caused a transient pressure rise followed by prolonged hypotension. When administered during the dark phase, neither drug caused a pressure rise but both drugs caused prolonged hypotension. It was concluded that ibopamine and epinephrine cause identical intraocular pressure changes in the normal rabbit eye. The effect was dependent on the timing of administration during the circadian cycle. Since ibopamine is a pro-drug of deoxyepinephrine (N-methyl dopamine, epinine), its effects are assumed to be due to this metabolite, a metabolite that is structurally similar to epinephrine.
本研究的目的是测量局部应用异波帕明和肾上腺素对未受干扰的家兔眼压的影响。六只有色家兔配备了一个遥测换能器系统，该系统通过导管连接到一只眼睛的玻璃体腔，用于连续监测眼压。在适应12小时光照、12小时黑暗周期且眼压昼夜节律稳定后，给动物使用2%异波帕明和2%肾上腺素。每种药物在昼夜周期的光照期和黑暗期滴注。在光照期给药时，两种药物均引起短暂的眼压升高，随后是长时间的低血压。在黑暗期给药时，两种药物均未引起眼压升高，但均导致长时间的低血压。得出的结论是，异波帕明和肾上腺素在正常兔眼中引起相同的眼压变化。这种效应取决于昼夜周期中的给药时间。由于异波帕明是脱氧肾上腺素（N-甲基多巴胺，去甲伪麻黄碱）的前体药物，其作用被认为是由于这种代谢产物，一种在结构上与肾上腺素相似的代谢产物。
