Latimer D C, Roth B J
Mathematical Institute, University of Oxford, U.K.
IEEE Trans Biomed Eng. 1999 May;46(5):612-4. doi: 10.1109/10.759063.
Using a three-dimensional model of cardiac tissue, we consider a rectangular slab of tissue. We examine the effect of a defibrillating shock from an intracavitary electrode upon the epicardial transmembrane potential (Vm) for two cases: one in which the epicardium is bounded by air and another in which it is bounded by a conductive bath. We find that the inclusion of the bath changes the polarity of the steady-state Vm in the epicardial region that is closest to the shock electrode. In addition, the magnitude of Vm is increased dramatically if the bath is present; the degree of hyperpolarization increases twenty-fivefold, while the degree of depolarization increases elevenfold. The remaining bulk of the cardiac tissue is relatively unaffected by the inclusion of the bath.
使用心脏组织的三维模型，我们考虑一块矩形组织块。我们研究了两种情况下腔内电极除颤电击对心外膜跨膜电位（Vm）的影响：一种情况是心外膜以空气为边界，另一种情况是心外膜以导电浴为边界。我们发现，加入导电浴会改变最靠近电击电极的心外膜区域稳态Vm的极性。此外，如果存在导电浴，Vm的幅度会显著增加；超极化程度增加25倍，而去极化程度增加11倍。心脏组织的其余大部分相对不受加入导电浴的影响。
