Dodds L, King W, Woolcott C, Pole J
Reproductive Care Program of Nova Scotia, Halifax, Canada.
Epidemiology. 1999 May;10(3):233-7.
We conducted a retrospective cohort study to evaluate the relation between the level of total trihalomethanes in drinking water and adverse birth outcomes. The study population comprised women residing in an area with municipal surface water who had a singleton birth in Nova Scotia between January 1, 1988, and December 31, 1995, or a pregnancy termination for a major fetal anomaly. We found little association between trihalomethane level and the outcomes related to fetal weight or gestational age, but we found an elevated relative risk for stillbirths for average trihalomethane levels during pregnancy of 100 microg/liter or greater (adjusted relative risk = 1.66; 95% confidence interval = 1.09-2.52) relative to women exposed to trihalomethane levels of 0-49 microg/liter. We saw little evidence of an elevated prevalence or dose-response pattern for congenital anomalies, with the possible exception of chromosomal abnormalities (adjusted prevalence ratio = 1.38 and 95% confidence interval = 0.73-2.59 for women exposed to trihalomethane levels of 100 microg/liter or greater).
我们进行了一项回顾性队列研究，以评估饮用水中总三卤甲烷水平与不良出生结局之间的关系。研究人群包括居住在使用城市地表水地区的妇女，她们于1988年1月1日至1995年12月31日在新斯科舍省单胎分娩，或因严重胎儿畸形而终止妊娠。我们发现三卤甲烷水平与胎儿体重或孕周相关结局之间几乎没有关联，但我们发现，与暴露于三卤甲烷水平为0 - 49微克/升的妇女相比，孕期平均三卤甲烷水平为100微克/升或更高时，死产的相对风险升高（调整后的相对风险 = 1.66；95%置信区间 = 1.09 - 2.52）。我们几乎没有发现先天性异常的患病率升高或剂量反应模式的证据，染色体异常可能是个例外（暴露于三卤甲烷水平为100微克/升或更高的妇女，调整后的患病率比 = 1.38，95%置信区间 = 0.73 - 2.59）。
