通过皮下注射毛果芸香碱诱导饮水。

Drinking induced by parenteral injections of pilocarpine.

作者信息

Gay P E, Benner S C, Leaf R C

出版信息

Pharmacol Biochem Behav. 1976 Dec;5(6):633-8. doi: 10.1016/0091-3057(76)90304-x.

Abstract

Parenteral (IP) injections of pilocarpine, in doses from 3.75 - 30 mg/kg, reliably produced drinking in water-satiated rats. This effect was not diminished by pretreatment with either centrally active (scopolaime, atropine) or peripherally active (methyl scopolamine, methyl atropine) cholinergic blocking agents, suggesting that pilocarpine does not induce drinking via a cholingergic meachnism. Repated injections of low doses, but not high doses, of pilocarpine augments drinking over trials.

摘要

腹腔注射毛果芸香碱，剂量为3.75 - 30毫克/千克，能可靠地使饮水充足的大鼠产生饮水行为。用中枢活性（东莨菪碱、阿托品）或外周活性（甲基东莨菪碱、甲基阿托品）胆碱能阻断剂预处理后，这种效应并未减弱，这表明毛果芸香碱并非通过胆碱能机制诱导饮水。重复注射低剂量而非高剂量的毛果芸香碱会使多次试验中的饮水增加。