对与Babyhaler、Volumatic和Aerochamber储雾罐装置一起使用的丙酸倍氯米松、昔萘酸沙美特罗和丙酸氟替卡松定量吸入器的颗粒大小输出进行的比较分析。
A comparative analysis of the particle size output of beclomethasone diproprionate, salmeterol xinafoate and fluticasone propionate metered dose inhalers used with the Babyhaler, Volumatic and Aerochamber spacer devices.
作者信息
Barry P W, O'callaghan C
机构信息
Department of Child Health, University of Leicester, Leicester, UK.
出版信息
Br J Clin Pharmacol. 1999 Apr;47(4):357-60. doi: 10.1046/j.1365-2125.1999.00900.x.
AIMS
To determine in vitro the effect of delay, inspiratory flow, and spacer washing on the drug output of metered dose inhalers (MDIs) used with different spacer devices.
METHODS
The amount of drug in particles <5 microm diameter from MDI+spacer, sampling after a delay of up to 20 s, was measured using a Multistage Liquid Impinger. Drug output was also measured at different flow rates, and after washing the Babyhaler in household detergent.
RESULTS
More fluticasone in small particles was recovered from the Babyhaler than the Volumatic or the Aerochamber spacers, and more beclomethasone and salmeterol was recovered from the Babyhaler and Volumatic spacers than from the Aerochamber. Washing the Babyhaler reduced the recovery of salmeterol, and did not alter the recovery of the other drugs tested.
CONCLUSIONS
Spacer devices need to be fully evaluated for each drug prescribed for them.
目的
在体外确定延迟、吸气流速和储雾罐清洗对与不同储雾罐装置联用的定量吸入器（MDIs）药物输出量的影响。
方法
使用多级液体冲击器测量MDI+储雾罐在延迟长达20秒后采集的直径<5微米颗粒中的药物量。还在不同流速下以及用家用洗涤剂清洗婴儿储雾罐后测量药物输出量。
结果
从婴儿储雾罐中回收的小颗粒中氟替卡松比容积式储雾罐或空气室储雾罐更多，从婴儿储雾罐和容积式储雾罐中回收的倍氯米松和沙美特罗比空气室储雾罐更多。清洗婴儿储雾罐降低了沙美特罗的回收率，且未改变所测试的其他药物的回收率。
结论
对于为其开具的每种药物，储雾罐装置都需要进行全面评估。
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