气单胞菌临床和环境分离株中两种溶血毒素基因的分布：与乳鼠模型中毒力的相关性
Distribution of two hemolytic toxin genes in clinical and environmental isolates of Aeromonas spp.: correlation with virulence in a suckling mouse model.
作者信息
Heuzenroeder M W, Wong C Y, Flower R L
机构信息
Infectious Disease Laboratory, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia.
出版信息
FEMS Microbiol Lett. 1999 May 1;174(1):131-6. doi: 10.1111/j.1574-6968.1999.tb13559.x.
Previous studies have shown that two hemolytic toxins, HlyA and AerA, contribute to the virulence of Aeromonas hydrophila. A survey was performed to gauge the distribution of hlyA and aerA genes in clinical and environmental Aeromonas isolates. For A. hydrophila, A. veronii biotype sobria and A caviae, 96%, 12% and 35% of strains, respectively, were hlyA positive, whereas, 78%, 97%, 41%, respectively, were aerA positive. All virulent A. hydrophila isolates were hlyA+ aerA+. This genotype was most common in A. hydrophila (75.4%) followed by A. caviae (29.4%) and A. veronii biotype sobria (9.6%). For A. hydrophila, a two-hemolytic toxin model of virulence provides the best prediction of virulence in an animal model.
先前的研究表明，两种溶血毒素HlyA和AerA有助于嗜水气单胞菌的毒力。开展了一项调查以评估hlyA和aerA基因在临床和环境来源的气单胞菌分离株中的分布情况。对于嗜水气单胞菌、维氏气单胞菌温和生物型及豚鼠气单胞菌，分别有96%、12%和35%的菌株hlyA呈阳性，而aerA呈阳性的菌株分别为78%、97%和41%。所有强毒嗜水气单胞菌分离株均为hlyA+ aerA+。这种基因型在嗜水气单胞菌中最为常见（75.4%），其次是豚鼠气单胞菌（29.4%）和维氏气单胞菌温和生物型（9.6%）。对于嗜水气单胞菌，双溶血毒素毒力模型能最好地预测动物模型中的毒力。
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