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[几种脊椎动物脊髓、延髓和小脑中央核中天冬氨酸转氨酶活性的组织化学研究]

[Histochemical study of the activity of aspartate aminotransferase in the spinal cord, the medulla oblongata and the central cerebellar nuclei of several vertebrates].

作者信息

Garcia-Segura L M, Martinez-Rodriguez R, Toledano A

出版信息

Z Mikrosk Anat Forsch. 1976;90(2):248-60.

PMID:1023552
Abstract

The aspartate aminotransferase activity (AAT) is reserched into the spinal cord, the medulla oblongata and the cerebellar nuclei of the rat, chicken, Lacerta lepida and Bufo calamitas. It's proved that the AAT activity shows in many locations, that are mainly: 1. In the nerve fibers 2. In the cytoplasmic membrane, and in the nuclear membrane of the neurons 3. In all neuronal cytoplasm, and 4. In the mitochondria of neurons and choroid plexus cells. The results base the idea that there's more than one pool of glutamic acid in relation to that AAT. It's suggested that the role that AAT plays is different in everyone of the described locations, and may be it's connected with transport phenomenons in the membrane, with energetic function on the mitochondria and with functions of the nerve impulse transmission in the synapsis. We remark, finally, the interest that the enzymatical works can have the time comming to establish homologies among similar structures of several animal's nervous system.

摘要

对大鼠、鸡、麻蜥和中华大蟾蜍的脊髓、延髓和小脑核中的天冬氨酸转氨酶活性(AAT)进行了研究。结果表明,AAT活性在许多部位都有表现,主要包括:1. 在神经纤维中;2. 在神经元的细胞质膜和核膜中;3. 在所有神经元的细胞质中;4. 在神经元和脉络丛细胞的线粒体中。这些结果支持了这样一种观点,即与AAT相关的谷氨酸不止一个池。有人认为,AAT在上述每个部位所起的作用都不同,可能与膜中的转运现象、线粒体的能量功能以及突触中神经冲动的传递功能有关。最后,我们指出,酶学研究对于确定几种动物神经系统相似结构之间的同源性可能具有重要意义。

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