Ormai S, Varga L, Papp M, Varró V
Acta Med Acad Sci Hung. 1976;33(1):89-93.
3H-gastrin (0.83 mug/rat) or 14C-glycine-pentapeptide amide (100 mug/rat) were injected into the femoral vein in various groups of rats and radioactivity was measured in the arterial blood plasma and thoracic duct lymph in consecutive 5--10 min. periods for 60 minutes. Radioactivity excreted in the bile for 30 minutes was injected into the blood and lymph was followed for 120 minutes. It has been observed that labelled gastrin or pentagastrin activity reaches its peak in the plasma in the 5th minute after intravenous injection. Next, activity in the plasma decreased after the injection of labelled gastrin, but remained unchanged after the injection of labelled pentagastrin. In the lymph, radioactivity reached its peak value between 5--15 min. after the injection of the labelled hormones. This peak value was two- to threefold of plasma radioactivity measured at the same periods. After the intravenous injection of labelled pentagastrin radioactivity was excreted in the bile; injecting this radioactive bile into the jejunal lumen, radioactivity was reabsorbed mainly into the blood circulation.
向不同组的大鼠股静脉注射3H - 胃泌素（0.83微克/只大鼠）或14C - 甘氨酸 - 五肽酰胺（100微克/只大鼠），并在接下来的60分钟内，以连续5 - 10分钟的时间段测量动脉血浆和胸导管淋巴中的放射性。将30分钟内胆汁中排出的放射性物质注入血液，并追踪淋巴120分钟。据观察，标记的胃泌素或五肽胃泌素活性在静脉注射后第5分钟时在血浆中达到峰值。接下来，注射标记胃泌素后血浆中的活性下降，但注射标记五肽胃泌素后活性保持不变。在淋巴中，放射性在注射标记激素后5 - 15分钟之间达到峰值。该峰值是同一时期测量的血浆放射性的两到三倍。静脉注射标记的五肽胃泌素后，放射性物质在胆汁中排出；将这种放射性胆汁注入空肠腔后，放射性物质主要被重新吸收进入血液循环。
