Wills H, Villarreal H
Arch Inst Cardiol Mex. 1976 Nov-Dec;46(6):770-5.
A study was made of the effect of ciclofosfamide on the nephrotic syndrome, glomecular filtration rate, immuproteins clearance complement, and urinary sediment in 14 patients with membranoproliferative glomerulonephritis. It was found that the nephrotic syndrome disappeared in 7 out of 8 cases, the glomerular filtration rate increased significantly in 13 out of 14 patients, and there was no correlation between the action of the drug and the behavior of the immunoglobulins clearances, complement, and the urinary sediment. Neither was there found a correlation between the increased renal function and the histological spectrum.
对14例膜增生性肾小球肾炎患者进行了一项关于环磷酰胺对肾病综合征、肾小球滤过率、免疫蛋白清除率、补体及尿沉渣影响的研究。结果发现，8例中有7例肾病综合征消失，14例中有13例肾小球滤过率显著升高，且药物作用与免疫球蛋白清除率、补体及尿沉渣表现之间无相关性。肾功能增加与组织学谱之间也未发现相关性。
