锂对大鼠肝脏诱导酶的影响。
Effects of lithium on inducible enzymes of rat liver.
作者信息
Grier G W, Davis L C, Pfeifer W D
出版信息
Horm Metab Res. 1976 Sep;8(5):379-83. doi: 10.1055/s-0028-1093618.
PMID:10240
Abstract
Chronic lithium administration to female rats results in elevation of serum corticoids, lowering of serum glucose and altered induction of liver enzymes. The cortisol induction of tyrosine transaminase is increased selectively over that of tryptophan oxygenase. The glucose induction of glucokinase following a fast is increased by chronic lithium treatment but diminished by acute treatment. These results indicate that lithium may alter the glucose metabolic set-point in rats.
摘要
对雌性大鼠长期施用锂会导致血清皮质激素升高、血清葡萄糖降低以及肝脏酶诱导的改变。酪氨酸转氨酶的皮质醇诱导相对于色氨酸加氧酶的诱导选择性增加。禁食后葡萄糖激酶的葡萄糖诱导在长期锂治疗后增加，但在急性治疗后减少。这些结果表明锂可能会改变大鼠的葡萄糖代谢设定点。
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