[Histopathology and histochemistry of a focus of staphylococcal infection in a sensitized body (material concerning pathogenesis)].

Rabbits were sensitized with a killed St. aureus culture (alpha-toxigenic 0-15 strain); one week later the were infected intradermally with a virulent leukocidin-active St. aureus V8 or with the 0-15 strain. A hyperegic inflammation with the signs of reaction observed in hypersensitivity of delayed type was revealed at the site of infection in 24 hours. On the seond day this process was supervened by an intensive leukocytic infiltration characteristic of this infection, with the subsequent suppuration. Beginning from the earliest stages of the process and up to its decline the inflammatory exudate displayed hyaluronic and sialic acids; they could perform functions of the nonspecific immunity factors in the focus. It was revealed at the terminal stage of the process that the organism did not react by the inflammatory reaction to the presence of the microbes remaining near the focus. Consequently, the tolerance of the organism to the microbe was revealed; this tolerance was possibly conditioned by the presence of sialic acids in the focus. Leukocytes with the phagocytized microbes appeared in the veins nearest to the focus. Histochemical shifts in the focus can be the cause of the incompleteness of phagocytosis. The tropism of staphylococci of the V8 strain to the collagen fibers was revealed.