Bogomolova N S, Suskova V S, Chernov V A, Serebriakov N G
Farmakol Toksikol. 1976 Nov-Dec;39(6):742-6.
Blood content, distribution among organs and tissues and passage from the organism of prospidine-C14 in rats, following its introduction per os and application to the skin in the form of an ointment, were studied. With these modes of introduction it is shown that prospidine and/or products of its biotransformation are capable of relatively quickly penerating through the wall of the gastro-intestinal tract and skin. However, specific radioactivity in the organs in such cases is scores of time lower than with intravenous administration. In case of the peroral introduction of the compound 72.3 per cent of the amount of the compound and/or of its metabolites administered are eliminated via the gastro-intestinal tract in two days.
研究了大鼠经口摄入和以软膏形式涂抹于皮肤后，丙哌卡因 - C14在大鼠体内的血药含量、在各器官和组织中的分布以及从机体的排出情况。通过这些给药方式表明，丙哌卡因和/或其生物转化产物能够相对较快地穿透胃肠道壁和皮肤。然而，在这种情况下，各器官中的比放射性比静脉注射时低数十倍。经口给予该化合物时，给药量的72.3%的化合物和/或其代谢产物在两天内通过胃肠道排出。
