Soon J A
Can J Hosp Pharm. 1980 Sep-Oct;33(5):158-61, 164.
The study of 826 geriatric nursing home patients was undertaken by a pharmacist to determine the incidence of adverse reactions to drugs. A formalized adverse drug reaction reporting program was used as the basis for the detection of unwanted drug effects. Approximately 27% of patients experienced a moderate to severe adverse effect. Five groups of drugs accounted for three-quarters of the reactions detected. The majority of these reactions were predictable and preventable. Females over the age of 70 on large quantities of drugs were significantly more susceptible to experiencing an adverse reaction. Physicians implemented 76% of pharmacist initiated recommendations for the treatment of adverse effects and were appreciative of increased pharmacy involvement. The implementation of such recommendations was felt to have substantially reduced the incidence of drug-induced acute hospitalizations. Although the information was generated in nursing homes, it may be generalized to other geriatric specialty areas such as medical wards and extended care units. Several recommendations are provided on how other pharmacists can implement similar clinical services in their areas of professional practice.
一名药剂师对826名老年疗养院患者进行了研究，以确定药物不良反应的发生率。一个正式的药物不良反应报告程序被用作检测不良药物效应的基础。约27%的患者经历了中度至重度不良反应。五组药物占所检测到反应的四分之三。这些反应大多是可预测和可预防的。70岁以上服用大量药物的女性更容易出现不良反应。医生实施了药剂师提出的76%的不良反应治疗建议，并对药剂科更多的参与表示赞赏。这些建议的实施被认为大幅降低了药物引起的急性住院发生率。尽管这些信息是在疗养院收集的，但也可推广到其他老年专科领域，如内科病房和长期护理病房。文中还提供了一些建议，说明其他药剂师如何在其专业实践领域实施类似的临床服务。
