韦弗小鼠小脑树突棘和神经胶质细胞的膜特化：一项冷冻蚀刻研究。
Membrane specializations of dentritic spines and glia in the weaver mouse cerebellum: a freeze-fracture study.
作者信息
Hanna R B, Hirano A, Pappas G D
出版信息
J Cell Biol. 1976 Mar;68(3):403-10. doi: 10.1083/jcb.68.3.403.
Abstract
Electron microscopy of thin-sectioned and freeze-fractured preparations of the cerebellum of the weaver mouse indicates that the dendritic spines are morphologically identical to those of their normal littermates. The weaver dendritic spines have been characterized as "unattached" since the synaptic input from the parallel fibers is absent (8-10). The entire region around the dendritic spines is taken up by astrocytic processes in the weaver. The outer fracture face of a normal dendritic spine contains aggregations of 10-nm wide particles in the immediate postsynaptic region. Similar particle aggregations occur in the unattached spines of the weaver. Freeze-fracture preparations reveal rectilinear arrays of particles, having a 7-nm center-to-center distance in the glial membranes. Rectilinear arrays are apparently distributed throughout the astrocyte membrane.
摘要
对韦弗氏小鼠小脑的薄切片和冷冻断裂标本进行电子显微镜观察表明，其树突棘在形态上与其正常同窝小鼠的树突棘相同。由于缺乏来自平行纤维的突触输入，韦弗氏小鼠的树突棘被描述为“未附着”（8 - 10）。在韦弗氏小鼠中，树突棘周围的整个区域都被星形胶质细胞的突起占据。正常树突棘的外断裂面在紧邻突触后区域含有10纳米宽的颗粒聚集。类似的颗粒聚集也出现在韦弗氏小鼠未附着的树突棘中。冷冻断裂标本显示，颗粒呈直线排列，在胶质膜中的中心间距为7纳米。直线排列显然分布在整个星形胶质细胞膜上。
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