Ensom R J, Godwin C C, Nakagawa R S
Can J Hosp Pharm. 1982 Sep-Oct;35(5):135-42.
Recently, there has been much emphasis on the value of "Therapeutic Drug Monitoring" (TDM). TDM includes clinical attention to the appropriateness, efficacy, side effects and toxicity of drug usage as it relates to the pharmacokinetics of the drug in the patient. The goal of TDM is to optimize drug therapy in each patient through the appropriate choice, dose and monitoring of drug use. The Drug Measurement Service (DMS) at St. Paul's Hospital is a cooperative venture of the departments of medicine, laboratories and pharmacy. The main function of the DMS is TDM. Also, the service educates staff physicians, residents and interns in the proper use and interpretation of serum drug levels. This will make future drug level measurements more beneficial to the patient. This paper outlines the need for a TDM service, the structure and activities of the service, the materials and methods used, and the basic pharmacokinetics and dosing recommendations of the first drug monitored (theophylline). The results of the first six months' experience are presented and discussed.
最近，“治疗药物监测”（TDM）的价值受到了广泛关注。TDM包括临床关注药物使用的适当性、疗效、副作用和毒性，因为这些与药物在患者体内的药代动力学有关。TDM的目标是通过适当选择、剂量和监测药物使用，优化每位患者的药物治疗。圣保罗医院的药物检测服务（DMS）是医学、实验室和药学部门的合作项目。DMS的主要功能是TDM。此外，该服务还对在职医生、住院医生和实习医生进行血清药物水平正确使用和解读方面的培训。这将使未来的药物水平检测对患者更有益。本文概述了TDM服务的必要性、该服务的结构和活动、所使用的材料和方法，以及所监测的第一种药物（茶碱）的基本药代动力学和给药建议。并呈现和讨论了前六个月的经验结果。
