Gorianov O A
Farmakol Toksikol. 1976 May-Jun;39(3):280-3.
Test staged on rats have brought evidence that lithium chloride acts damagingly on all parts of the nephron, inhibiting, first of all, the processes of filtration and then of secretion and reabsorption. Polyuria arising under the effect of lithium is caused by reduced reabsorption of water in the tubules and anuria--by depression of the glomerular filtration.
在大鼠身上进行的试验已得出证据,表明氯化锂对肾单位的所有部分都有损害作用,首先抑制滤过过程,然后抑制分泌和重吸收过程。锂作用下产生的多尿是由肾小管中水重吸收减少引起的,而无尿则是由肾小球滤过受抑制所致。