Suppr超能文献

[无血平、海利多尔、地巴唑和氨茶碱对血液纤维蛋白原含量及纤溶活性的影响]

[Effect of no-shpa, halidor, dibazol and euphylline on the fibrinogen content and fibrinolytic activity of blood].

作者信息

Ivleva A Ia, Kremneva V F, Zolotukhin S I

出版信息

Farmakol Toksikol. 1976 May-Jun;39(3):304-8.

PMID:1026513
Abstract

With a single intravenous administration to albino rats of both sexes of nospanum and halidor in a dose of 2 mg/kg and dibazol--in 1 mg/kg produce activation of fibrinolysis, while euphylline in a dose of 12 mg/kg has no effect on this process. A protracted introduction by the subcuataneous route of halidor and nospanum in a dose of 10 mg/kg, of dibazol--in 5 mg/kg and of euphylline intramuscularly in a dose of 24 mg/kg depresses in animals the activity of the proteolytic process. It was found that in vitro nospanum, halidor and dibazol accelerate fibrinolysis, whereas the presence of euphylline in the blood plasma deccelerates this process.

摘要

给雌雄白化大鼠静脉注射剂量为2毫克/千克的诺司帕明和海利多,以及剂量为1毫克/千克的地巴唑,可激活纤维蛋白溶解,而剂量为12毫克/千克的氨茶碱对此过程无影响。以10毫克/千克的剂量皮下长期注射海利多和诺司帕明,5毫克/千克的剂量皮下长期注射地巴唑,以及24毫克/千克的剂量肌肉内长期注射氨茶碱,会抑制动物体内蛋白水解过程的活性。研究发现,体外实验中诺司帕明、海利多和地巴唑可加速纤维蛋白溶解,而血浆中氨茶碱的存在会减缓这一过程。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验