Ivleva A Ia, Kremneva V F, Zolotukhin S I
Farmakol Toksikol. 1976 May-Jun;39(3):304-8.
With a single intravenous administration to albino rats of both sexes of nospanum and halidor in a dose of 2 mg/kg and dibazol--in 1 mg/kg produce activation of fibrinolysis, while euphylline in a dose of 12 mg/kg has no effect on this process. A protracted introduction by the subcuataneous route of halidor and nospanum in a dose of 10 mg/kg, of dibazol--in 5 mg/kg and of euphylline intramuscularly in a dose of 24 mg/kg depresses in animals the activity of the proteolytic process. It was found that in vitro nospanum, halidor and dibazol accelerate fibrinolysis, whereas the presence of euphylline in the blood plasma deccelerates this process.
给雌雄白化大鼠静脉注射剂量为2毫克/千克的诺司帕明和海利多,以及剂量为1毫克/千克的地巴唑,可激活纤维蛋白溶解,而剂量为12毫克/千克的氨茶碱对此过程无影响。以10毫克/千克的剂量皮下长期注射海利多和诺司帕明,5毫克/千克的剂量皮下长期注射地巴唑,以及24毫克/千克的剂量肌肉内长期注射氨茶碱,会抑制动物体内蛋白水解过程的活性。研究发现,体外实验中诺司帕明、海利多和地巴唑可加速纤维蛋白溶解,而血浆中氨茶碱的存在会减缓这一过程。