Zashikhin A L
Arkh Anat Gistol Embriol. 1976 Dec;71(12):43-9.
Histological, histochemical and neurochemical methods were used in order to study the features of the histogenesis of structures of the atrioventricular area of the conducting system of the heart and the formation of their cholinergic innervation in the postnatal period of the hog. Under study were 175 hearts of embryos of the hog at the age of 3, 4, 5, 6, 8, 10, 12, 14 and 15 weeks and 22 hearts of adult hogs. The formation of different areas of this system was shown to be asynchronous. The atrioventricular fascicle is formed during the 4th week, the atrioventricular node -- during the 6th week and the conducting muscle fibres--during the 8th week of embryogenesis. The fascicle and the node have a complicated structure and different cellular composition. In the process of prenatal ontogenesis the increased amount of glycogen and increased activity of phosphorylase were noted in the cytoplasm of myocytes of the atrioventricular area of the conducting system of the heart. The cholinergic nerve fibres grow up to the structures of the atrioventricular area of the conducting system of the heart during the 6th week of embryogenesis, and by the end of the prenatal development they form a thick network in all its structures.
为了研究猪出生后心脏传导系统房室区结构的组织发生特征及其胆碱能神经支配的形成，采用了组织学、组织化学和神经化学方法。研究对象为175个3、4、5、6、8、10、12、14和15周龄猪胚胎的心脏以及22个成年猪的心脏。结果表明，该系统不同区域的形成是不同步的。房室束在胚胎发育第4周形成，房室结在第6周形成，传导肌纤维在第8周形成。束和结结构复杂，细胞组成不同。在产前个体发育过程中，心脏传导系统房室区心肌细胞的细胞质中糖原含量增加，磷酸化酶活性增强。胆碱能神经纤维在胚胎发育第6周生长至心脏传导系统房室区结构，并在产前发育结束时在其所有结构中形成密集网络。
