Sokolina N A, Il'ina N A, Korolev V V
Arkh Patol. 1976;38(9):27-33.
The article presents data on the clinico-morphological study of three patients suffering from thyrotoxicosis with attacks of periodic paralysis. The muscles obtained by biopsy in two patients at the moment of attack and in one patient--in the absence of attack were investigated by the electron microscopy method. The data obtained make it possible to assume that in the thyrotoxic periodic paralysis the action of the thyroid hormones causes not only impairment of the mineral metabolism, but brings about changes in the structure of the membranes of the sarcolemma and T-system, which leads to disturbances of conductance of action potential into the fibre. These changes affect the function of the end cisterns and lead to distorsion of the processes of conjugation of excitation-contraction with resulting development of paresis and paralysis of muscles. Moreover, during the attack there take place secondary disturbances of carbohydrate metabolism, which aggravates the pathological process.
本文介绍了对三名患有甲状腺毒症并伴有周期性麻痹发作的患者进行临床形态学研究的数据。通过电子显微镜方法对两名患者发作时及一名患者未发作时活检获取的肌肉进行了研究。所获得的数据使我们能够推测，在甲状腺毒症性周期性麻痹中，甲状腺激素的作用不仅会导致矿物质代谢紊乱，还会引起肌膜和T系统膜结构的变化，从而导致动作电位传入纤维的传导障碍。这些变化影响终池的功能，并导致兴奋 - 收缩偶联过程的扭曲，进而导致肌肉麻痹和瘫痪。此外，发作期间会发生碳水化合物代谢的继发性紊乱，这会加重病理过程。
