• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450.

作者信息

Hjelmeland L M, Aronow L, Trudell J R

出版信息

Biochem Biophys Res Commun. 1976 May 23;76(2):541-9. doi: 10.1016/0006-291x(77)90758-6.

DOI:10.1016/0006-291x(77)90758-6
PMID:1027445
Abstract
摘要

相似文献

1
Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450.
Biochem Biophys Res Commun. 1976 May 23;76(2):541-9. doi: 10.1016/0006-291x(77)90758-6.
2
Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450.细胞色素P-450催化的羟基化反应中取代基效应的分子内测定
Mol Pharmacol. 1977 Jul;13(4):634-9.
3
Prochiral selectivity and intramolecular isotope effects in the cytochrome P-450 catalyzed omega-hydroxylation of cumene.
Biochemistry. 1986 Nov 18;25(23):7336-43. doi: 10.1021/bi00371a015.
4
Intramolecular isotope effects associated with meta-hydroxylation of biphenyl catalyzed by cytochrome P-450.
Biochem Biophys Res Commun. 1984 Feb 14;118(3):867-72. doi: 10.1016/0006-291x(84)91475-x.
5
Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation.人细胞色素P450及肝微粒体催化的7-烷氧基香豆素O-脱烷基反应的动力学氘同位素效应。细胞色素P450 1A2底物氧化中限速C-H键的断裂。
FEBS J. 2006 May;273(10):2223-31. doi: 10.1111/j.1742-4658.2006.05235.x.
6
Cytochrome P450-catalyzed hydroxylation of hydrocarbons: kinetic deuterium isotope effects for the hydroxylation of an ultrafast radical clock.细胞色素P450催化的碳氢化合物羟基化反应：超快自由基时钟羟基化反应的动力学氘同位素效应
Biochemistry. 1994 Sep 6;33(35):10630-7. doi: 10.1021/bi00201a009.
7
Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4'-dimethylbiphenyl by cytochrome P450: relationship between distance of methyl groups and masking of the intrinsic isotope effect.
Biochemistry. 1997 Jun 10;36(23):7136-43. doi: 10.1021/bi962810m.
8
Cumene hydroperoxide-supported denitrification of 2-nitropropane in uninduced mouse liver microsomes.
Int J Biochem. 1986;18(7):595-601. doi: 10.1016/0020-711x(86)90239-9.
9
Kinetic isotope effects implicate two electrophilic oxidants in cytochrome p450-catalyzed hydroxylations.动力学同位素效应表明，细胞色素P450催化的羟基化反应中有两种亲电氧化剂。
J Am Chem Soc. 2003 May 21;125(20):6064-5. doi: 10.1021/ja0343858.
10
Evidence against an abstraction or direct insertion mechanism for cytochrome P-450 catalysed meta hydroxylations.
Biochem Biophys Res Commun. 1982 Jan 29;104(2):626-32. doi: 10.1016/0006-291x(82)90683-0.

引用本文的文献

1
Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions.细胞色素P450反应中的动力学氘同位素效应
Methods Enzymol. 2017;596:217-238. doi: 10.1016/bs.mie.2017.06.036. Epub 2017 Jul 18.
2
Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps.人细胞色素 P450 2A6 对 N-亚硝基烷胺的氧化：醛和羧酸的顺序氧化及反应步骤分析。
J Biol Chem. 2010 Mar 12;285(11):8031-44. doi: 10.1074/jbc.M109.088039. Epub 2010 Jan 8.
3
Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes.
细菌和人类细胞色素P450酶催化烃类氧化过程中的自由基中间体
Biochemistry. 2006 Jan 17;45(2):533-42. doi: 10.1021/bi051840z.
4
Intermolecular and intramolecular isotope effects in the deamination of putrescine catalyzed by diamine oxidase.
Experientia. 1982 Apr 15;38(4):431-3. doi: 10.1007/BF01952622.