Wong S T, Desser S S
J Protozool. 1978 Aug;25(3 Pt 2):302-14. doi: 10.1111/j.1550-7408.1978.tb03896.x.
The schizogonic development of Leucocytozoon dubreuili in the kidney proximal tubule cells of the American robin, Turdus migratorius, was studied by electron microscopy. Renal schizogony is initiated by the entry of certain hepatic merozoites into cells of the proximal tubules. Development of the schizont consists of coordinated sequence of events including extensive mitotic nuclear division, multiplication of mitochondria, increase in endoplasmic reticulum and ribosomes, differentiation of membranes, microtubules, micronemes and rhoptries, and cytoplasmic segmentation (cytomere formation). Merozoites form by budding around numerous centers in the schizont and, when mature, are bounded by a single plasma membrane subtended by microtubules. Each merozoite contains a large nucleus, a mitochondrion, and well developed apical complex consisting of 3 polar rings, paired rhoptries, and numerous micronemes. An atypical nuclear division observed in some maturing schizonts was characterized by the multiple fission of a nucleus within a persistent outer nuclear membrane and the absence of mitotic spindle apparatus. Alterations in infected renal cells consisted of disorganization and loss of cytoplasmic organelles and the accumulation of lipofuscin-like inclusions.
通过电子显微镜研究了杜氏白细胞虫（Leucocytozoon dubreuili）在美国知更鸟（旅鸫，Turdus migratorius）肾近端小管细胞中的裂体生殖发育。肾裂体生殖由某些肝裂殖子进入近端小管细胞引发。裂殖体的发育包括一系列协调的事件，包括广泛的有丝分裂核分裂、线粒体增殖、内质网和核糖体增加、膜、微管、微线体和棒状体的分化以及细胞质分割（形成细胞块）。裂殖子通过在裂殖体内的多个中心周围出芽形成，成熟时被微管支撑的单个质膜包围。每个裂殖子含有一个大核、一个线粒体以及由3个极环、成对的棒状体和众多微线体组成的发育良好的顶复合器。在一些成熟裂殖体中观察到的非典型核分裂的特征是，在持续存在的外核膜内细胞核进行多次分裂且无有丝分裂纺锤体装置。受感染肾细胞的变化包括细胞质细胞器的紊乱和丢失以及脂褐素样内含物的积累。
