Iuzhakov S D
Farmakol Toksikol. 1976 Sep-Oct;39(5):562-5.
Tests conducted on anesthetized rats with experimental renal hypertension demonstrated that octadine, reserpine and methyl-DOPA with their one-time administration produce at the onset of the maximal hypotensine effect of fall of the arterial pressure at the expense of the lowered total peripheral resistance. Most characteristic of the action exercised by these drugs is an increased fraction of the cardiac ejection going to the gestro-intestinal tract. In hypertension all the substances under study reduce the coronary and splenic fractions of the cardiac ejection. Reserpine and methyl-DOPA do not change, while octadine reduces the fraction of the cardiac ejection that goes to the kidney.
在麻醉的实验性肾性高血压大鼠身上进行的试验表明，奥他定、利血平和甲基多巴一次性给药后，会通过降低总外周阻力，在动脉压下降达到最大降压效果开始时起效。这些药物作用的最显著特点是进入胃肠道的心脏射血分数增加。在高血压状态下，所有研究的物质都会降低心脏射血的冠状动脉和脾脏部分。利血平和甲基多巴没有变化，而奥他定降低了进入肾脏的心脏射血分数。
