Beketov A I, Svistov V V, Tkachenko B I, Krasil'nikov V G
Farmakol Toksikol. 1977 Mar-Apr;40(2):162-6.
In tests staged on anesthetized cats the effects of reserpine, isobarine and dopegit upon the resistance of cerebral vessels were studied resistographically. In 60--120 minutes after their introduction these drugs raise the resistance of intracranial vessels, inhibiting their reaction to electric stimulation of sympathic nerves and bringing down at the same time the total arterial pressure. An inference is drawn to the effect that the mounting perfusion pressure in the cerebral vessels following the action of reserpine and isobarine occurs as a result of their alpha-adrenoreceptors stimulation with norepinephrine that is intensively secreted from the nerve endings. Dopegit exerts an analogous action through formation of alpha-methyl-norepinephrine, which produces, like norepinephrine, an effect on the cerebral vessels.
在对麻醉猫进行的实验中，用电阻抗描记法研究了利血平、异波帕明和多培沙明对脑血管阻力的影响。在注射这些药物后的60 - 120分钟内，这些药物会提高颅内血管的阻力，抑制其对交感神经电刺激的反应，同时降低总动脉压。由此推断，利血平和异波帕明作用后脑血管灌注压升高是由于它们刺激神经末梢大量分泌去甲肾上腺素，从而激活α - 肾上腺素能受体所致。多培沙明通过形成α - 甲基去甲肾上腺素发挥类似作用，α - 甲基去甲肾上腺素与去甲肾上腺素一样，对脑血管产生影响。
