Gudelsky G A, Simpkins J, Mueller G P, Meites J, Moore K E
Neuroendocrinology. 1976;22(3):206-15. doi: 10.1159/000122627.
The effects of prolactin (PRL) administration on catecholamine turnover in various brain regions of ovariectomized rats were determined by observing the decline of dopamine and norepinephrine concentrations after alpha-methyltyrosine (alphaMT) administration. PRL had no effect on the steady state concentration of dopamine in the median eminence, anterior hypothalamus and corpus striatum or on the norepinephrine concentration in the anterior hypothalamus. However, PRL selectively enhanced dopamine turnover in the median eminence and anterior hypothalamus after a latent period of 10-26 h. In addition, PRL administration significantly decreased serum concentrations of LH and FSH. These results suggest that the PRL-induced increase in activity of dopaminergic neurons in the median eminence or anterior hypothalamus may be responsible for the reduction of the post-castration rise in serum concentrations of LH and FSH.
通过观察给予α-甲基酪氨酸（αMT）后多巴胺和去甲肾上腺素浓度的下降，确定了催乳素（PRL）给药对去卵巢大鼠不同脑区儿茶酚胺代谢的影响。PRL对正中隆起、下丘脑前部和纹状体中多巴胺的稳态浓度或下丘脑前部去甲肾上腺素的浓度没有影响。然而，在10-26小时的潜伏期后，PRL选择性地增强了正中隆起和下丘脑前部的多巴胺代谢。此外，PRL给药显著降低了血清促黄体生成素（LH）和促卵泡生成素（FSH）的浓度。这些结果表明，PRL诱导的正中隆起或下丘脑前部多巴胺能神经元活性增加可能是导致去势后血清LH和FSH浓度升高降低的原因。
