Bellinger L L, Bernardis L L, Mendel V E
Neuroendocrinology. 1976;22(3):216-25. doi: 10.1159/000122628.
Weanling rats received bilateral electrolytic lesions in the dorsomedial (DMH) or ventromedial (VMH) hypothalamic areas destroying primarily the dorsomedial (DMN) or ventromedial (VMN) hypothalamic nuclei. Sham-operated rats served as controls. Lesions in the VMN and DMN, both of which have previously been shown to disrupt normal diurnal feeding rhythms, were also observed to disrupt normal plasma corticosterone rhythms in the present study. The a.m. values of plasma corticosterone in the DMN-lesioned rats were higher than the sham-operated controls. In the p.m., the values of both VMN- and DMN-lesioned rats were lower than those of the controls but unchanged in comparison to their own a.m. concentrations. This disruption of the normal diurnal plasma corticosterone rhythm persisted for at least 9 post-operative weeks.
断奶大鼠在双侧下丘脑背内侧（DMH）或腹内侧（VMH）区域接受电解损伤，主要破坏下丘脑背内侧核（DMN）或腹内侧核（VMN）。假手术大鼠作为对照。VMN和DMN的损伤，此前已被证明会扰乱正常的昼夜进食节律，在本研究中也观察到会扰乱正常的血浆皮质酮节律。DMN损伤大鼠的上午血浆皮质酮值高于假手术对照组。在下午，VMN和DMN损伤大鼠的值均低于对照组，但与它们自己上午的浓度相比没有变化。正常昼夜血浆皮质酮节律的这种破坏持续了至少术后9周。
