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关于一名氨肽尿症患者的研究。I. 尿中氨肽的鉴定。

Studies on a patient with iminopeptiduria. I. Identification of urinary iminopeptides.

作者信息

Kodama H, Umemura S, Shimomura M, Mizuhara S, Arata J, Yamamoto Y, Yasutake A, Izumiya N

出版信息

Physiol Chem Phys. 1976;8(5):463-73.

PMID:1029019
Abstract

A patient suffering from recurrent ulcers on the legs was found to excrete large amounts of iminodipeptides in the urine. Among the iminodipeptides excreted, Glu-Hyp, Asp-Pro, Glu-Pro, Leu-Hyp, Gly-Pro, Thr-Pro, Ser-Pro, Ala-Pro, Val-Pro, Ile-Pro, Leu-Pro, and Phe-Pro were identified and their quantities estimated. Some of the iminopeptides had to be synthesized for purposes of identification.

摘要

一名患有腿部复发性溃疡的患者被发现尿液中排泄大量亚氨基二肽。在所排泄的亚氨基二肽中，鉴定出了谷氨酸 - 羟脯氨酸、天冬氨酸 - 脯氨酸、谷氨酸 - 脯氨酸、亮氨酸 - 羟脯氨酸、甘氨酸 - 脯氨酸、苏氨酸 - 脯氨酸、丝氨酸 - 脯氨酸、丙氨酸 - 脯氨酸、缬氨酸 - 脯氨酸、异亮氨酸 - 脯氨酸、亮氨酸 - 脯氨酸和苯丙氨酸 - 脯氨酸，并对它们的量进行了估算。为了鉴定目的，一些亚氨基肽必须进行合成。

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J Inherit Metab Dis. 1982;5(2):111-3. doi: 10.1007/BF01800003.
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Increased manganese content and reduced arginase activity in erythrocytes of a patient with prolidase deficiency (iminodipeptiduria).一名患有脯氨酰二肽酶缺乏症（亚氨基二肽尿症）患者红细胞中锰含量增加且精氨酸酶活性降低。
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