生物胺对胎鼠和新生鼠生长激素分泌的调控

Biogenic amine control of growth hormone secretion in the fetal and neonatal rat.

作者信息

Stuart M, Lazarus L, Smythe G A, Moore S, Sara V

出版信息

Neuroendocrinology. 1976;22(4):337-42. doi: 10.1159/000122642.

Abstract

The development of the hypothalamic-pituitary axis for growth hormone (GH) secretion has been studied in the rat fetus and in the neonate 4, 24, 48 and 72 h after birth. Injections of the serotonin blocker cyproheptadine (Cypro) and a catecholamine, dopamine (DA), each led to reductions in the level of serum GH in 21 to 22 day fetuses and in neonates up to 3 days after birth. The O-methylated derivative of dopamine, dimethoxyphenylethylamine (DMPEA), did not alter serum GH levels from those seen in saline-treated control animals. These results indicate that biogenic amines exert control over GH secretion in the fetus, close to term, and in early neonatal period. They suggest that this control is similar to that seen in the adult rat and in man and that such control may operate through serotonin receptors.

摘要

人们已在大鼠胎儿以及出生后4小时、24小时、48小时和72小时的新生儿中，对下丘脑 - 垂体轴分泌生长激素（GH）的发育情况展开了研究。注射血清素阻断剂赛庚啶（Cypro）和一种儿茶酚胺——多巴胺（DA），均会导致21至22日龄胎儿以及出生后3天内新生儿的血清GH水平降低。多巴胺的O - 甲基化衍生物二甲氧基苯乙胺（DMPEA），并未使血清GH水平相较于生理盐水处理的对照动物出现变化。这些结果表明，生物胺在接近足月的胎儿期以及新生儿早期对GH分泌发挥着调控作用。它们提示，这种调控作用与成年大鼠和人类中观察到的情况相似，且这种调控可能通过血清素受体发挥作用。